Here is the full text of a pilot study on the effects of an oral contraceptive on a group of obese women, some with PCOS and the rest (the control group) without.

The researchers were specifically looking at what happens to the level of insulin resistance/sensitivity to these women when they start taking a particular oral contraceptive.

From the discussion:

After 3 months of OC use, we found significant worsening of glucose tolerance (AUC glucose) in PCOS women compared to control women. There was no significant difference between the two groups in other metabolic parameters at the end of 3 months.

While the glucose tolerance seem to worsen for the PCOS group, the measured level of insulin resistance did not. However, insulin sensitivity did worsen for the women in the control group:

Hence, it appears that when insulin sensitivity is already profoundly reduced at baseline, as in the case of the combination of both PCOS and obesity, the effect of OCs in further reducing insulin sensitivity may not be evident. This may explain why only control women, but not PCOS women, experienced a significant increase in fasting insulin, and worsening of insulin sensitivity after 3 months of OC when compared to baseline.

The full paper is available online, so please have a look at it yourself! It is a very small pilot study, but it is great news that all these factors are being studied.

It’s a big step in the right direction, especially when so many women (and men) have never heard of PCOS or thought twice about the possible metabolic effects of oral contraceptives.

(*Note: I haven’t had the time to look in-depth at the stats in the paper. I’m just so damn happy to see something like this which will hopefully get funding for a bigger, and scientifically rigorous, study.)

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